Always use colored paper, which is available at all photocopy stores. It can be useful to keep colored paper on hand in order to create fliers with one’s own printer. Reams with several different colors are available.
Fliers are primarily visual, so lay them out effectively. Again, create a focal point for the eye, but make sure the pertinent information is there.
Distribute the fliers by giving some to everyone involved in the event or business. Have these people pass them out to everyone they meet, put them in mail boxes at work, pass them out to neighbors, etc.